Effectiveness of Statin and Bisphosphonate Treatment in a 3NP model of Huntington’s Disease

Effectiveness of Statin and Bisphosphonate Treatment in a 3NP model of Huntingtonâ•Žs Disease

Economic Analysis of Bisphosphonate Use after Distal Radius Fracture for Prevention of Hip Fracture

Background: Osteoporosis is a common condition among the elderly population, and is associated with an increased risk of fracture. One of the most common fragility fractures involve the distal radius, and are associated with risk of subsequent fragility fracture. Early treatment with bisphosphonates has been suggested to decrease the population hip fracture burden. However, there have been no p...

Neuroprotective effect of Zingiber officinale in 3-np-induced huntington disease

–Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disease that causes clinical manifestations such as progressive choreiformic movements, cognitive abnormality and psychiatric deterioration. HD results from the destruction of neurons in the basal ganglia, and oxidative stress, Exitotoxicity and energy impairment hasbeen implicated in its pathogenesis. 3-Nitropropio...

Growth Hormone Deteriorates the Functional Outcome in an Experimental Model of Huntington’s Disease Induced by 3-Nitropionic Acid

BACKGROUND AND PURPOSE Growth hormone (GH) has been frequently used to control the aging process in healthy individuals, probably due to its slowing effect on senescence-associated degeneration. Mitochondrial dysfunction is related to the aging process, and one of the chemical models of Huntington's disease is that it can be induced by mitochondrial toxin. To investigate the potential applicati...

Effect of Statin Treatment on COVID-19 Patients’ Outcomes: A Randomized Double-blind Controlled Clinical Trial

Background: Statins may be protective against viral infection and have been suggested for the treatment of coronavirus disease 2019 (COVID-19).  Objective: In this study, we aimed to evaluate the effect of atorvastatin on COVID-19 patients. Methods: Our study is a randomized double-blind controlled clinical trial that constitutes a population of COVID-19 patients admitted to Bu-Ali Sina Hospi...